Уважаемые пользователи!

Данный сайт содержит информацию для людей с медицинским образованием и специалистов здравоохранения.
Входя на сайт, Вы подтверждаете свое согласие с Условиями использования и Политикой конфиденциальности.



Dear visitor!
This site contains medical information for healthcare professionals.
You can go further, if you agree with Terms and Conditions and Privacy Policy on this site.

Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis

Cover Page

Abstract


Aim.
 To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM.
Materials and Methods.
A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with established AIT comorbidity or elevation of anti-thyroid autoantibodies (ATA). Patients with isolated T1DM (ATA-negative) formed the second group. HLA-genotyping was performed by multiprimer PCR set for the three following genes: DRB1, DQA1 and DQВ1.
Results.
 Prevalence of alleles DRB1*01, *03(017), *04, *07, *11 and genotypes 01/03, 01/04, 03/04 tends to be higher among patients with AIT comorbidity. The comorbidity group was also characterized by the trend towards higher prevalence of ?marker/marker? and ?marker/non-marker? combinations favouring the former variant. Conversely, ATA-negative patients exhibited trend for higher prevalence of ?non-marker/non-marker? combination.
Conclusion.
Statistically insignificant difference between HLA II alleles and genotypes in the two studied groups suggests that primary genetic factors are common in these two diseases. Plausibly, genes other than DRB1, DQA1 and DQВ1 determine the localization of the autoimmune process.

Ekaterina Alexandrovna Repina

Endocrinology Research Centre, Moscow

Author for correspondence.
Email: e_repina@mail.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник лаборатории генетики и клинической иммунологии ФГБУ ЭНЦ

Tatiana Mikhailovna Atamanova

Endocrinology Research Centre, Moscow

Email: e_repina@mail.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник лаборатории генетики и клинической иммунологии ФГБУ ЭНЦ

Yana Stanislavovna Zvereva

Endocrinology Research Centre, Moscow

Email: e_repina@mail.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник лаборатории генетики и клинической иммунологии ФГБУ ЭНЦ

Yulia Vladimirovna Tishina

Endocrinology Research Centre, Moscow

Email: e_repina@mail.ru

Russian Federation научный сотрудник лаборатории генетики и клинической иммунологии  ФГБУ ЭНЦ

Sergey Alexandrovich Prokof'ev

Endocrinological Research Centre, Moscow

Email: e_repina@mail.ru

Russian Federation кандидат медицинских наук, заведующий лабораторией генетики и клинической иммунологии ФГБУ ЭНЦ

  1. Алексеев ЛП, Дедов ИИ, Хаитов РМ, Болдырева МН, Шестакова МВ, Петеркова ВА, и др. Клиническая значимость определения HLA-DRB1-генотипов, ассоциированных с предрасположенностью или устойчивостью к сахарному диабету 1 типа в различных этнических группах России. Сахарный диабет. 2007;(2):2–5. [Alekseev L, Dedov I, Khaitov R, Boldyreva M, Shestakova M, Peterkova V, et al. Klinicheskaya znachimost' opredeleniya HLA-DRB1-genotipov, assotsiirovannykhs predraspolozhennost'yu ili ustoychivost'yuk sakharnomu diabetu 1 tipa,v razlichnykh etnicheskikh gruppakh Rossii. Diabetes mellitus. 2007;(2):2–5. doi: 10.14341/2072-0351-5787 ].
  2. Дедов ИИ, Шестакова МВ. Сахарный диабет. Руководство для врачей. Москва: Универсум Паблишинг. 2003. С. 77–81. [Dedov II, Shestakova MV. Diabetes mellitus. Guidelines for Physicians. Moscow: Universum Publishing; 2003.]
  3. Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, et al. Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proceedings of the National Academy of Sciences. 1998;95(17):9979–9984. doi: 10.1073/pnas.95.17.9979
  4. Encinas JA, Kuchroo VK. Mapping and identification of autoimmunity genes. Curr Opin Immunol 2000;12(6):691–697. doi: 10.1016/S0952-7915(00)
  5. Bias WB, Reveille JD, Beaty TH, Meyers DA, Arnett FC. Evidence that autoimmunity in man is a Mendelian dominant trait. The American Journal of Human Genetics. 1986;39(5):584–602.
  6. McCanlies E, O'Leary LA, Foley TP, Kramer MK, Burke JP, Libman A, et al. Hashimoto's thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin. Endocrinol Metab. 1998;1998(5):1548–1551. doi: 10.1210/jc.83.5.1548
  7. Dittmar M, Kahaly GJ. Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endocrinol Metab 2003;88(7):2983–2992. doi: 10.1210/jc.2002-021845
  8. Levin L, Tomer Y. The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility Autoimmunity Reviews. 2003;2(6):377–386. doi: 10.1016/S1568-9972(03)00080-6
  9. Huber A, Menconi F, Corathers S, Jacobson EM, Tomer Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocrine Review. 2008;29(6):697–725. doi: 10.1210/er.2008-0015
  10. Репина ЕА. Общие генетические маркеры сахарного диабета 1 типа и аутоиммунных заболеваний щитовидной железы. Сахарный диабет. 2011;(2):23–30. [Repina E. The role of common genetic markers in susceptibility to type 1 diabetes and autoimmune thyroid diseases. Diabetes mellitus. 2011;(2):23-31. doi: 10.14341/2072-0351-5630 ]
  11. Burek CL, Rose NR, Guire KE, Hoffman WH. Thyroid autoantibodies in black and in white children and adolescents with type 1 diabetes mellitus and their first degree relatives Autoimmunity. 1990;7(2–3):157–167.
  12. Jaeger C, Hatziagelaki E, Petzoldt R, Bretzel RG. Comparative Analysis of Organ-Specific Autoantibodies and Celiac Disease – Associated Antibodies in Type 1 Diabetic Patients, Their First-Degree Relatives, and Healthy Control Subjects. Diabetes Care. 2001;24(1):27–32. doi: 10.2337/diacare.24.1.27
  13. Sougioultzoglou F, Falorni A, Kassi G, Brozzetti A, Karamitsos D, Koliakos GG. Coincidence of high antiislet and antithyroid autoantibody titles in first-degree relatives of patients with type 1 diabetes. Experimental and Clinical Endocrinology & Diabetes. 2005; 113(2):85–89. doi: 10.1055/s-2005-837510.
  14. Kordonouri O, Deiss D, Danne T, Dorow A, Bassir C, Grüters-Kieslich A. Predictivity of thyroid autoantibodies for the development of thyroid disorders in children and adolescents with Type 1 diabetes. Diabet Med. 2002;19(6):518–521. doi: 10.1046/j.1464-5491.2002.00699.x
  15. Bright GM, Blizzard RM, Kaiser DL, Clarke WL. Organ-specific autoantibodies in children with common endocrine diseases. The Journal of Pediatrics. 1982;100(1):8–14.
  16. Eisenbarth GS, Gottlieb PA. Autoimmune Polyendocrine Syndromes. New England Journal of Medicine. 2004;350(20):2068–2079. doi: 10.1056/NEJMra030158
  17. Wallaschofski H, Meyer A, Tuschy U, Lohmann T. HLA-DQA1*0301-associated susceptibility for autoimmune polyglandular syndrome type II and III. Hormone and Metabolic Research. 2003.;35(2):120–124. doi: 10.1055/s-2003-39059.
  18. Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Journal of Clinical Endocrinology and Metabolism 1994;78(4):878–883. doi: 10.1210/jc.78.4.878
  19. Santamaria P, Barbosa JJ, Lindstrom AL, Lemke TA, Goetz FC, Rich SS. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Journal of Clinical Endocrinology and Metabolism 1994;78(4):878–883. doi: 10.1210/jc.78.4.878.
  20. Levin L, Ban Y, Concepcion E, Davies TF, Greenberg DA, Tomer Y. Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. Human Immunology. 2004;65(6):640–647. doi: 10.1016/j.humimm.2004.02.026
  21. Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y. Genetic Analysis of Families with Autoimmune Diabetes and Thyroiditis: Evidence for Common and Unique Genes. Journal of Clinical Endocrinology and Metabolism. 2005;90(8):4904–4911. doi: 10.1210/jc.2004-2236
  22. Huang W, Connor E, Rosa TD, Muir A, Schatz D, Silverstein J, et al. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity. Journal of Clinical Endocrinology and Metabolism. 1996;81(7):2559–2563. doi: 10.1210/jc.81.7.2559
  23. Holl RW, Bohm B, Loos U, Grabert M, Heinze E, Homoki J. Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Effect of age, gender and HLA type. Hormone Research. 1999;52(3):113–118. doi: 10.1159/000023446
  24. Никонова ТВ, Дедов ИИ, Алексеев ЛП, Болдырева МН, Смирнова ОМ, Дубинкин ИВ. Сахарный диабет. 2000;(2):2–5. DOI: [Nikonova T, Dedov I, Alekseev L, Boldyreva M, Smirnova O, Dubinkin I. Prognozirovanie SD 1 tipa v gruppakh vysokogo riska. Diabetes mellitus. 2000;(2):2–6. doi: 10.14341/2072-0351-5877 ]
  25. Болдырева МН, Хаитов РМ, Дедов ИИ, Богатова ОВ, Гуськова ИА, Янкевич ТЭ, и др. Новый взгляд на механизм HLA ассоциированной предрасположенности к сахарному диабету 1 типа. Теоретические и прикладные аспекты. Иммунология. 2005;26(6):324–329. [Boldyreva МN, Khaitov RМ, Dedov II, Bogatova ОV, Gus'kova IA, Yankevich ТЕ, et al. New opinion at the mechanism of HLA-associated predisposition to 1 type diabetes: theoretical and applied aspects. Immunology. 2005;26(6):324–329].

Views

Abstract - 1301

PDF (Russian) - 919

HTML (Russian) - 915

Cited-By


PlumX


Copyright (c) 2013 Repina E.A., Atamanova T.M., Zvereva Y.S., Tishina Y.V., Prokof'ev S.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies