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Markers for gastrointestinal autoimmune disorders in patients with type 1 diabetes mellitus

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Abstract


Aim.
 to assess the occurrence of autoantibodies characteristic of autoimmune pancreatitis and gastritis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects.
Materials and Methods.
 84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination.
Results.
 Markers for gastrointestinal autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to instrumental diagnostic methods.
Conclusion.
Our data suggests that T1DM patients are at higher risk of corresponding, possibly asymptomatic autoimmune disorders.

Olga Sergeevna Derevyanko

Endocrinology Research Centre, Moscow

Author for correspondence.
Email: shapovalyants@yahoo.com

Russian Federation postgraduate student

Nadezhda Sergeevna Dalantaeva

Endocrinology Research Centre, Moscow

Email: post@endocrincentr.ru

Russian Federation postgraduate student

Elena Vladimirovna Pekareva

Endocrinology Research Centre, Moscow

Email: pekarevaev@mail.ru

Russian Federation MD, PhD, Senior Researcher in Diabetic Education and treatment department

Olga Nikolaevna Ivanova

Endocrinology Research Centre, Moscow

Email: post@endocrincentr.ru

Russian Federation PhD, Leading Researcher, Head of genetic and clinical immunology laboratory

Nikolay Petrovich Goncharov

Endocrinology Research Centre, Moscow

Email: post@endocrincentr.ru

Russian Federation MD, PhD, Professor, Head of laboratory for hormone analisis

Tatiana Vasil'evna Nikonova

Endocrinology Research Centre, Moscow

Email: tatiana_nikonova@mail.ru

Russian Federation MD, PhD, Leading Researcher in Diabetic education and treatment department

Olga Mikhailovna Smirnova

Endocrinology Research Centre, Moscow

Email: dr_smr@mail.ru

Russian Federation MD, PhD, Professor, Chief Researcher in Diabetic education and treatment department

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Copyright (c) 2013 Derevyanko O.S., Dalantaeva N.S., Pekareva E.V., Ivanova O.N., Goncharov N.P., Nikonova T.V., Smirnova O.M.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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