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Hormonal, electrolyte disturbances and features of hemostasis in term newborn infants of mothers with gestational diabetes mellitus.

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Abstract


The article reviews the available data on investigations in the field of electrolyte (calcium, magnesium), hormonal (insulin, leptin) and hemostasis disturbances in term newborns from women with gestational diabetes; possible mechanisms of their development are also highlighted. The review describes changes in blood glucose concentration in term newborns from women with gestational diabetes, and their impact on the child's condition. In addition to already known factors causing macrosomia and other metabolic disorders in term neonates, the role of leptin (peptide hormone that regulates energy metabolism) is quite discussable. Low leptin levels lead to the development of obesity. It is also confirmed, that leptin influences brain development of the newborn, leading to later cognitive deficits in children from women with GDM.
The aim of the review is to summarize the available data on investigations in the field of electrolyte (calcium, magnesium), hormonal (insulin, leptin) and hemostasis disturbances in term newborns from women with gestational diabetes.

Evgeny Viktorovich Mikhalev

Siberian State Medical University, Tomsk

Email: mikhalev-ev@yandex.ru

Russian Federation MD, Professor, Head of the Department of Pediatrics CPP and PPP

Olga Michailovna Shanina

Siberian State Medical University, Tomsk

Author for correspondence.
Email: shaninao@inbox.ru

Russian Federation graduate student of the Department of Pediatrics CPP and PPP

Tatiana Vladimirovna Saprina

Siberian State Medical University, Tomsk

Email: tanja.v.saprina@mail.ru

Russian Federation PhD, Associate Professor of Diabetology and Endocrinology

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