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The рopulation сomposition of lymphocyte and the rate of infection by by the herpes simplex virus in patients ill with autoimmune autoimmune thyroiditis

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Abstract


The objective of the research is the analysis of blood lymphocyte composition and the rate of infection by the herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in patients with AIT. Two men and twenty six women (with the average age 44.0 ± 2.3 years) ill with the disease for 6.0 ± 2.7 years were examined. 85.7% of the ill were in the euthyroid state, 14.3% were in hypothyroidism. 25% ofthe patients were diagnosed with atrophic AIT, 60,7% got the diagnoses of fibroid and fibronodular AIT and 14.3% got hypertrophic AIT diagnoses. It was found that the course of AIT was accompanied with the increase of the rate of CD20 +-lymphocytes in blood at the normal number of CD3 +-, CD4 +-, CD8 +- и CD56 + cells. The IgG to the HSV was found in 92.9% patients with AIT, to the CMV - in 96.4% cases, to the pre-early antigen (ЕА) of CMV (acute infection) - in 39.3% patients and to the nuclear antigen of EBV (КА) (late past-infection) - in 67.6% cases. In two cases we found EBV-IgG to EA and КА simultaneously (late stage of primary EBV-infection or reactivation of its chronic form). It was proved that 39.3% of the patients with AIT associate this disease with acute cytomegalovirus infection.

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