Polymorphism Glu389Arg of β1-adrenoreceptor gene and cardiovascular complications of hyperthyroidism

Cover Page


Gly389Arg polymorphism β1-adrenoreceptors can influence the cardio-vascular prognosis. Human heart β1-adrenoreceptors perform a crucial role in mediating the cardiostimulant effects of norepinephrine. Understanding the significance of Gly389Arg polymorphism in the human heart is beginning to emerge, but not in adult patients with thyrotoxicosis. We've studied the Gly389Arg polymorphism of β1-adrenoreceptors gene in relation to Echo-cardiography parameters in 136 normotensive patients with a thyrotoxicosis without any CVD. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. The genotype distribution was as following: Gly/Gly – 25% (1 group (1 gr.)), Arg/Gly – 75% (2 group (2 gr.), Arg/Arg – 0%. There was significant difference between 1 and 2 gr. by relative left ventricle wall thickness, left ventricular mass index, isovolumic relaxation time, Е/А ratio. The frequency of diastolic dysfunction (DD) was in gr. 1–10%, in gr. 2–30%, р <0.001. After treatment during a year this damages were saved. These data demonstrate, that Gly/Gly genotype of β1-adrenoreceptors gene can have cardioprotective effect leading to less of LV hypertrophy and diastolic dysfunction in patients with thyrotoxicosis.

About the authors

Email: alina_babenko@mail.ru


  1. Bahouth S.W. Thyroid hormones transcriptionally regulate the β1-adrenergic receptor gene in cultured ventricular myocytes // J. Biolog. Chem. 1991. V. 266. Р. 15 863–15 869.
  2. Bengtsson K., Melander O., Orho Melander M. et al. Polymorphism in the β1-adrenergic receptor gene and hypertension // Circulation. 2001. V. 104. Р. 187–190.
  3. Jones A., Montgomery H. The Gly389Arg β1-adrenoceptor polymorphism and cardiovascular disease: time for a rethink in the funding of genetic studies? // Eur. Heart. J. 2002. V. 23. P. 1071–1074.
  4. Magbool A., Hall A.S., Ball S.G., Balmforth A.J. Common polymorphisms of β1-adrenoreceptor: identification and rapid screening assay // Lancet. 1999. V. 353. Р. 897.
  5. Novotny J., Bourova L., Malkova O. et al. G proteins, beta-adrenoreceptors and beta-adrenergic responsiveness in immature and adult rat ventricular myocardium: influence of neonatal hypo- and hyperthyroidism // J. Mol. Cell. Cardiol. 1999. V. 31. Р. 761–772.
  6. Sandilands A. J., O’Shaughnessy K. M. and Brown M. J. Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 β-adrenoceptors versus Gly389 β-adrenoceptors in isolated human atrial myocardium // Br. J. Pharmacol. 2003. V. 138. Р. 386–392.
  7. Swan L., Birnie D.H., Padmanabhan S., Inglis G. et al. The genetic determination of left ventricular mass in healthy adults // Eur. Heart J. 2003. V. 24. N6. Р. 577–582.



Abstract - 804

PDF (Russian) - 295




Copyright (c) 2010 ., ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies