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The relationship of hormone-metabolic disorders and indicators of anxiety and depression in young men with obesity on different types of therapy

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Objective: to assess hormonal and metabolic parameters and psychological status of young men with obesity. Methods: The study included 60 men with obesity (BMI>30 kg/m2) divided in two groups. Patients in the first group (n=30) received orlistat for 12 weeks (120 mg 3 times daily with meal). Patients in second group (n=30) followed hypocaloric diet and aerobic exercise. All patients were examined before treatment and after 12 weeks. Evaluation included hormonal and biochemical analyses, 48 patients were examined by psychological questionnaires (Beck Depression Inventory, Beck Anxiety Inventory, Liebowitz Social Anxiety Scale, Dutch Eating Behavior Questionnaire). Results: Patients that received orlistat treatment showed significant decrease of body mass: 50% of patients had decrease more than 5%, 30% of patients - more than 10% (p<0,05). In first group after 12 weeks of treatment level of cortisol decreased and level of testosterone increased. The results of treatment in second group were less significant. There was a significant decrease in anxiety and depression scales in patients taking orlistat (p<0,05). High levels of social anxiety did not decrease in both groups after treatment. As a result of orlistat treatment there was a decrease in external eating behavior and increase in expression of restraint eating behavior by DEBQ (p<0,05). Conclusions: treatment with orlistat reduces body weight, which is correlated by improvement of hormonal and biochemical parameters. Weight loss is accompanied by changes in rates of anxiety and depression.

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Copyright (c) 2012 Tel'nova M.E., Kochetkov Y.A., Petunina N.A., Trukhina L.V., Perepelkina O.S.

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