Cindrom obstruktivnogo apnoe sna v praktikevracha-endokrinologa

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It is known, that sleep-disordered breathing can affect patients with various endocrine diseases. Obstructive, central and mixed
types of sleep apnea syndrome are known to occur in obesity, hypothyroidism, acromegaly, diabetes mellitus, especially with diabetic neuropathy,
Cushing syndrome and polycystic ovary syndrome. The pathogenic mechanisms and pathophysiology of оbstructive sleep apnea
in patients with different endocrine diseases, clinical manifestations and treatment of sleep apnea are reviewed in this article.

About the authors





  1. Вейн А.М., Елигулашвили Т.С., Полуэктов М.Г. Синдром апноэ во сне и другие расстройства дыхания, связанные со сном: клиника, диагностика, лечение. - Москва: Эйдос Медиа, 2002. - 310 С.
  2. Вейн А.М., Карлов А.В., Муртазаев М.С. Синдром сонных апноэ // Сов. мед. - 1988. - № 11. - С. 25-26.
  3. Елигулашвили Т.С. Неврологические аспекты синдрома апноэ во сне: клинико-фи- зиологическое исследование // Дисс. д-ра мед. наук. - М. - 1998.
  4. American Academy of Sleep Medicine Manual for Scoring Sleep, 2007.
  5. Brzecka A., Piesiak P., Zareba-Bogdał E., Zierkiewicz G., Plamieniak Z. Rhythm of melatonin excretion in obstructive sleep apnea syndrome // Pneumonologia i Alergologia Polska, 2001; 69(11-12): Р. 650-4.
  6. Deegan P.C., Mc Namara V.M., Morgan W.E. Goitre: A cause of obstructive sleep apnea in euthyroid patients // European Respiratory Journal, 1997; 10: Р. 500-2.
  7. Dexter D.D., Dovre E.J. Obstructive sleep apnea due to endogenous production in a woman // Mayo clinic proceedings, 1998; 73: Р. 246-8.
  8. Esra Tasali, Eve Van Cauter, David A. Ehrmann. Polycystic ovary syndrome and obstructive sleep apnea // Sleep medicine clinics, 2008. March; 3(1): Р. 37-46.
  9. Fatti L.M., Scacchi M., Pincelli A.I., Lavezzi E., Cavagnini F. Prevalence and pathogenesis of sleep apnea and lung disease in acromegaly // Pituitary, 2001 Sep.; 4(4): Р. 259-62.
  10. Jean-Louis G., Zizi F., Clark L.T., Brown C.D., McFarlane S.I. Obstructive Sleep Apnea and Cardiovascular Disease: Role of the metabolic syndrome and its components // Journal of Clinical Sleep Medicine, Vol. 4, №3, 2008: Р. 261-72.
  11. Gastaut H., Tassinari C.A., Duron B. Etude polygraphique des manifestations йpisodiques (hypniques et respiratoires) diurnes et nocturnes du syndrome de Pickwick // Rev. Neurol. 1965. V. 112. - P. 568-79.
  12. Gottlieb D.J., DeStefano A.L., Foley D.J., Mignot E., Redline S., Givelber R.J., Young T. APOE epsilon4 is associated with obstructive sleep apnea / hypopnea: the Sleep Heart Health Study // Neurology, 2004 Aug., 24; 63(4): Р. 664-8.
  13. Grunstein R.R., Ho K., Sullivan C. Sleep apnoea in acromegaly // Annals of Internal Medicine. - 1991. - Vol. 115. - P. 527-62.
  14. Grunstein R.R., Ho K.Y., Berthon-Jones M., Stewart D., Sullivan C.E. Central sleep apnoea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patient with acromegaly // American Journal of respiratory and critical care medicine. - 1994; 150: Р. 496-502.
  15. Harris A., Prestele H., Herold K., Boerlin V. Long-term efficacy of Sandostatin (SMS 201- 995, octreotide) in 178 acromegalic patients: results from the international multi-center acromegaly study group // Sandostatin in the treatment of acromegaly. - Spriger Verlag: Berlin. - 1988. - P. 117-25.
  16. Hernбndez C., Abreu J., Abreu P., Castro A., Jimйnez A. Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP // European Respiratory Journal, 2007, Sep.; 30(3): Р. 496-500.
  17. Keller T., Hader C., De Zeeuw J., Rasche K. Obstructive sleep apnea syndrome: the effect of diabetes and autonomic neuropathy. Journal of physiology and pharmacology: an official journal of the Polish Physiological society, 2007, Nov.; 58 Suppl. 5(Pt 1): 313-8.
  18. Logan A.G., Perlikowski S.M., Mente A., Tisler A., Tkacova R., Niroumand M., Leung R.S., Bradley T.D. High prevalence of unrecognized sleep apnoea in drugresistant hypertension // J. Hypertens, 2001, Dec.; 19 (12): Р. 2271-7.
  19. Mezon B.J., West P., Maclean J.P., Kryger M.H. Sleep apnea in acromegaly // American Journal of Medicine. - 1980. - Vol. 69. - P. 615-8.
  20. Misiolek M., Marek B., Namyslowski G., Scierski W., Zwirska-Korczala K., Kazmierczak-Zagorska Z., Kajdaniuk D., Misiolek H. Sleep apnea syndrome and snoring in patients with hypothyroidism with relation to overweight // Journal of the Physiology and Pharmacology, 2007, Mar.; 58, Suppl. 1: Р. 77-85.
  21. Palmer L.J., Buxbaum S.G., Larkin E., Patel S.R., Elston R.C., Tishler P.V., Redline S. A whole-genome scan for obstructive sleep apnea and obesity // American Journals of Human Genetics, 2003, Feb.; 72(2): Р. 340-50.
  22. Paolo Bottini, Claudio Tantucci. Sleep apnea syndrome in endocrine diseases. Respiration, 2003; 70: Р. 320-27.
  23. Pompeo A., Salutari P. Sudden death by sleep apnea syndrome associated with mixoedema. A case literature // Minerva Endocrinologica. 1999; 24: Р. 37-44.
  24. Raucher H., Popp W., Zwick H. Systemic hypertension in snorers with and without sleep apnea // Chest., 1992, Aug.; 102(2): Р. 367-71.
  25. Rosenov F., McCarthy V., Caruso A.C. Sleep apnoea in endocrine disease // Journal of Sleep Research, 1998; 7: Р. 3-11.
  26. Rosenov F., Reuter S., Szelies B. et al. Sleep apnoea in treated acromegaly: relative frequency and predisposing factors // Journal of Clinical Endocrinology. - 1996. - Vol. 45. - P. 563-9.
  27. Sanders M.H. Medical therapy for sleep apnea // Principles and Practice of sleep medicine: 2-nd ed. - Piladelphia: Harcourt Brace&Company,1994, Р. 678-93.
  28. Sanders M.H., Stiller R.A. Positive airway pressure in the treatment of sleep-related breathing disorders. Chokoverty, S eds. // Sleep disorders medicine, 1995, Р. 455- 72, Butterworth-Heinemann. Newton, M.A.
  29. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure // Hypertension 2003; 42: Р. 206-52.
  30. Shaver J.L., Zenk S.N. Sleep disturbance in menopause // Journal of Women's Health &Gender-Based Medicine, 2000; 9: Р. 109-18.
  31. The international classification of sleep disorders: Diagnostic and coding manual. - Kansas: Allen Press Inc., 2005.
  32. Vgontas A.N., Tan T.L., Bixter E.O., Martin L.F., Shubert D., Kales A. Sleep apnea and sleep disruption in obese patients // Archives of Internal Medicine 1994; 154: Р. 1705-11.
  33. Wilcox I., McNamara S.G. Collins FL et al. «Syndrome Z»: the interaction of sleep apneoa, vascular risk factors and heart disease // Thorax, 1998; 53, 3; Р. 25-28.
  34. Young T., Palta M., Dempsey J., Skatrud J., Weber S., Badr S. The occurrence of sleep-disordered breathing among middle-aged adults // The New England Journal of Medicine, 1993; 328(17): Р. 1230-5.
  35. Zhang X., Liu R.Y., Lei Z., Zhu Y., Huang J.A., Jiang X., Liu Z., Liu X., Peng X., Hu H., Zhang H.T. Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome // International Journal of Molecular Med., 2009, Apr.; 23(4): Р. 485-93.
  36. Young T., Evans L., Finn L., Palta M. Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep. 1997 Sep.; 20(9): Р. 705-6.



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