The value of blood serotonin for effective weight loss in obese women

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Introduction. Obesity is a disorder of energy balance, which leads to excessive accumulation of fat. In recent years, many important discoveries were made in this field, including the discovery of hormones produced by adipose tissue and the identification of many of the central and peripheral pathways of energy balance.

Objective. To study the levels of hormones that affect appetite and metabolism in women with obesity baseline and after weight loss while taking sibutramine.

Materials and methods. The study included 56 women aged 42,9±9,5 years, with a BMI of 34,6±6,1 kg/m2. All patients underwent clinical, laboratory and instrumental examination. Hormonal study included determination of serotonin, leptin, ghrelin, endothelin-1, adiponectin.

Results: In women with obesity we identified hyperleptinemia and increased serotonin levels. The decrease in body weight in patients receiving sibutramine was accompanied by lower levels of serotonin, leptin, ghrelin, endothelin-1, and increase of adiponectin.

Conclusions: Obese patients have significantly elevated levels of leptin, serotonin, ghrelin compared to women of normal weight. Sibutramine treatment leads to a decrease in serotonin, leptin, ghrelin and is more effective in women with a BMI less than 36,5 kg/m2.

Natal'ya Vadimovna Anikina

Perm State Medical University named after Academician EA Vagner

Author for correspondence.

Russian Federation Assistant of the Department of Endocrinology and Clinical Pharmacology

Elena Nikolaevna Smirnova

Perm State Medical University named after Academician EA Vagner


Russian Federation Sc.D., prof., Head of the Department of Endocrinology and Clinical Pharmacology

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Copyright (c) 2015 Аникина Н.В., Смирнова Е.Н.

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