Hormonal status and the orexin system in obese patients with obstructive sleep apnea syndrome


The aim of research was to estimate the influence of hormone metabolism and sleep apnea on patients with obesity. 76 patients (37 males and 39 females) with obesity were included in this study. After night polysomnography all patients were divided in two groups comparable
by age, sex ratio and BMI. The first group consisted of 41 patients with obstructive sleep apnea syndrome (OSAS), the second (controls) – 35 patients without breath disorders during sleep. OSAS is accompanied by the increase in urinary cortisol during the night, high levels of
basal insulin, disturbances of hepatic production of IGF-1, dysfunction of the pituitary-gonadal axis. Our results show that sleep-related breathing disorders render markedly and negatively affect on hormonal parameters of patients with obesity. As a reliable difference of basal
secretion of orexin A in obese patients with and without OSAS was not revealed (42,0 [14; 99,5] vs. 18,0 [14,5; 124,5] pg/ml; р=0,9), we were not able to show the existence that the existence of OSAS is followed by any special changes of activity of the orexin system.

About the authors

Natalya Viktorovna Strueva

Endocrinology Research Centre

Author for correspondence.
Email: nstr84@mail.ru

Russian Federation Ph.D student

Galina Afanas'evna Melnichenko

Endocrinology Research Centre

Email: melnich@endocrincentr.ru

Russian Federation MD, Ph.D. Academician of the Russian Academy of Sciences, Director of the  Clinical Endocrinology Institute

Mikhail Gur'evich Poluektov

I. M. Sechenov First Moscow State Medical University

Email: polouekt@mail.ru

Russian Federation PhD, Head of the Department of Sleep Medicine in I.M. Sechenov First Moscow State Medical University

Larisa Viktorovna Savel'eva

Endocrinology Research Centre

Email: larisa.savelieva@inbox.ru

Russian Federation Phd, Head of the Department of therapy treatment of endocrinopathies

Gulinara Viktorovna Katsya

Endocrinology Research Centre

Email: dmeno@rambler.ru
Sc.D, chief researcher of the Laboratory of Biochemical Endocrinology and hormonal analysis

Nikolay Petrovich Goncharov

Endocrinology Research Centre

Email: goncharovN@endocrincentr.ru

Russian Federation Sc.D., prof ., head of the Laboratory of Biochemical Endocrinology and hormonal analysis


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Copyright (c) 2015 Струева Н.В., Мельниченко Г.А., Полуэктов М.Г., Савельева Л.В., Кация Г.В., Гончаров Н.П.

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