Treatment with various forms of desmopressin in a patient with apparently non-idiopathic diabetes insipidus


Diabetes insipidus (DI) is a rare syndrome characterized by an excretion of abnormally large volumes of diluted urine and a corresponding increase in fluid intake. In the absence of treatment, patients with this disease experience significant difficulties due to the constant need to visit the toilet for urination and persistent thirst. Desmopressin, a synthetic analogue of the antidiuretic hormone, has been the treatment of choice for the central form of DI for many decades. Just like with any other hormone replacement therapies, the more accurately the dose is chosen for a particular patient, the better and safer the expected clinical response. In this article, we present a clinical case that demonstrates the clinical difficulties encountered in the treatment of a patient with central DI.

Ekaterina A Pigarova

Author for correspondence.
SPIN-code: 6912-6331
Endocrinology Research Centre, Moscow, Russia
Russian Federation, 117036, Россия, Москва, ул. Дм. Ульянова дом 11

PhD, leading researcher at the Neuroendocrinology and osteopathies Department

  • Motzfeldt K. Diabetes Insipidus. Endocrinology. 1918;2(2):112-121. doi: 10.1210/endo-2-2-112.
  • Juul KV, Bircher D, Nørgaard JP. Treatment of central diabetes insipidus. Ferring pharmaceuticals. 2014.
  • Oiso Y, Robertson GL, Nørgaard JP, Juul KV. Treatment of Neurohypophyseal Diabetes Insipidus. J. Clin. Endocr. Metab. 2013;98(10):3958-3967. doi: 10.1210/jc.2013-2326.
  • Пигарова Е.А. Центральный несахарный диабет: патогенетические и прогностические аспекты, дифференциальная диагностика. Дис. ... канд. мед. наук. – М; 2009. [Pigarova EA. Tsentral'nyy nesakharnyy diabet: patogeneticheskie i prognosticheskie aspekty, differentsial'naya diagnostika. [Dissertation]. Moscow; 2009. (In Russ.)] Доступно по:
  • Пигарова Е.А. Десмопрессин в диагностике и лечении центрального несахарного диабета // Ожирение и метаболизм. – 2013. – Т. 10. – №1. – C. 50-51. [Pigarova EA. Desmopressin in the diagnosis and treatment of central diabetes insipidus. Obesity and metabolism. 2013;10(1):50-51. (In Russ.)] doi: 10.14341/2071-8713-5073.
  • Пигарова Е.А., Дзеранова Л.К. Диагностика и лечение центрального несахарного диабета // Ожирение и метаболизм. – 2014. – Т. 11. – №4. – C. 48-55. [Pigarova EA, Dzeranova LK. Diagnosis and treatment of central diabetes insipidus. Obesity and metabolism. 2014;11(4):48-55. (In Russ.)] doi: 10.14341/omet2014448-55.


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