Vol 7, No 3 (2010)

Articles
Lechenie sakharnogo diabeta 2 tipa ingibitorami dipeptidilpeptidazy-4
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Abstract
Type 2 diabetes is difficult to manage and multiple therapeutic approach are usually needed. Moreover, addition to the initial treatment of most currently available oral antidiabetic agents increases the risk of hypoglycaemia and causes a weight gain. Dipeptidyl peptidase-IV inhibitors improve glycaemic control by increasing pancreatic beta cell responsiveness to glucose and suppressing inappropriate glucagon secretion. This article summarizes the data from randomized clinical trial in which efficacy and safety of vildagliptin were assessed.
Obesity and metabolism. 2010;7(3):3-6
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Sindrom khronicheskoy ustalosti: sovremennye predstavleniya ob etiologii
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Abstract
Chronic fatigue syndrome is a disease of unexplained feeling of profound fatigue lasting for more than 6 months. This fatigue is not relieved even after prolonged rest and is exacerbated after physical or mental work. More than 3000 scientific studies had proved that chronic fatigue syndrome is not a form of depression or hypochondria. It is a real somatic illness that results in professional, social and individual desadaptation. This article summarizes the contemporary etiological conceptions of this condition.
Obesity and metabolism. 2010;7(3):8-13
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Izbytochnyy ves i ozhirenie - problema meditsinskaya, a ne kosmeticheskaya
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Abstract
The article covers the issues of epidemiology, considering the classification of obesity, the risks of development of various somatic diseases related to overweight and obesity. The results of clinical studies of orlistat use in the treatment of obese patients are reported.
Obesity and metabolism. 2010;7(3):15-19
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Rasprostranennost' narusheniy svertyvayushchey i protivosvertyvayushchey sistem krovi u zhenshchin s metabolicheskim sindromom v postmenopauze
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Abstract
The object of the study was to assess the prevalence of prothrombotic alterations in coagulant and anticoagulant systems among postmenopausal women with metabolic syndrome and to determine the associations between these abnormalities and main anthropometric measures and parameters of glucose and lipid metabolism. Cross-sectional observational study included 55 postmenopausal women (age 45-65) with metabolic syndrome. Coagulant system was assessed by measurement of parameters of plasma haemostasis (prothrombin index, Activated Partial Thromboplastin Time (APTT), thrombin time, fibrinogen concentration), and the activities of coagulant factors VII (FVII) and VIII (FVIII) in plasma. In order to investigate the functioning of anticoagulant system the activities of antithrombin III and anticoagulant system of protein C were measured. Prothrombotic alterations were observed in 81,5% women. The APTT was decreased in 14,5%, hyperfibrinogenemia was revealed in 42,6%, the increased activity of FVII - in 50,9%, and the decreased activity of protein C system - in 23,9%. There were a significant positive associations between some of revealed prothrombotic alterations and anthropometric and biochemical markers of visceral obesity and metabolic syndrome (parameters of glucose and lipid metabolism). There were no any associations between haemostatic indices and age. In conclusion, there is an evidence of high prevalence of different prothrombotic alterations in coagulant and anticoagulant systems among postmenopausal women with metabolic syndrome. Metabolic syndrome in postmenopause is associated with the development of prothrombotic state independently of age.
Obesity and metabolism. 2010;7(3):21-27
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Spirograficheskie kharakteristiki patsientov s KhOBL i metabolicheskim sindromom v zavisimosti ot massy tela
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Abstract
It is known that low body mass index is a statistically significant predictor of death rate in patients with COPD. The purpose of our research comprised in evaluation of peculiarities of respiratory function parameters in patients with COPD and metabolic syndrome depending on body mass index. All patients were divided into groups: those who have only COPD, those who have combination of COPD and metabolic syndrome, they were subdivided into 3 subgroups, depending on body mass index (with normal body mass index, excess body mass index, and obesity). As a result of the research, it was found out that emphysematous respiratory disorders prevailed among patients with COPD and normal body mass index. Symptoms of obstructive bronchitis were found in patients with combination of COPD and metabolic syndrome, and excess body mass index values.
Obesity and metabolism. 2010;7(3):28-30
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Pishchevoe povedenie u molodykh muzhchin s ozhireniem, manifestirovavshim v pubertatnyy period
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Abstract
The aim of this study was to investigate the trends of feeding behavior in young men with obesity which was diagnosed at the time of puberty. For this we used the Holland questionnaire DEBQ, to assess level of depression - Beck's depression scale, for evaluation situational and individual anxiety - psychological testing "Integrative anxiety test". Long term duration of obesity was associated with more prominent emotional, external and restrictive behavior. This was accompanied also with higher rates of depression. Only restrictive feeding behavior was found to avert lasting weight loss. The formation of proper feeding behavior is to be initiated as earlier as possible at the treatment.
Obesity and metabolism. 2010;7(3):31-33
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Vliyanie ω-3-polinenasyshchennykh zhirnykh kislot na svobodnoradikal'nye protsessy i strukturnoe sostoyanie membran eritrotsitov u patsientov s metabolicheskim sindromom
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Abstract
This article presents data on tissue sensitivity to insulin, type of change in antioxidant-prooxidant system and membrane structure of erythrocytes in 30 patients from 20 to 58 years of age with metabolic syndrome who received a preparation of ω-3 polyunsaturated fatty acids. After 3 months of treatment with omacor we revealed the increase in the tissue insulin sensitivity, lowering of the free radical activity, normalization of antioxidant enzyme activity and erythrocytes membranes stabilization.
Obesity and metabolism. 2010;7(3):34-37
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Individualizatsiya terapii tsentral'nogo nesakharnogo diabeta: klinicheskiy sluchay primeneniya preparata «Presayneks»
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Abstract
Central diabetes insipidus (CDI) - a severe disease with disturbance of arginine vasopressin secretion, with excretion of large amounts of hypotonic urine, which leads to dehydration and thirst. Desmopressin, a synthetic analog of arginine vasopressin, is used to compensate a water-electrolyte balance in patients with CDI is available in forms of intranasal spray and tablets. Herein we present a clinical case of a patient with longstanding CDI due to Langerhans cell hystiocytosis in childhood who received different medications for treatment of CDI symptoms that demonstrates variable efficiency and tolerance of these drugs.
Obesity and metabolism. 2010;7(3):39-41
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Narushenie purinovogo obmena u patsienta s pervichnym giperparatireozom i sakharnym diabetom 2 tipa
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Abstract
In this article we describe a clinical case of primary hyperparathyroidism, gout tophus and diabetes mellitus type 2. The relationship between hyperuricemia and hypercalcemia linked to primary hyperparathyroidism is discussed.
Obesity and metabolism. 2010;7(3):43-48
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The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation
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Abstract
Obesity and metabolism. 2010;7(3):49-51
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Relationship between costs of lifestyle interventions and weight loss in overweight adults
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Abstract
Obesity and metabolism. 2010;7(3):51-52
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Evidence for statin therapy in polycystic ovary syndrome
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Abstract
Obesity and metabolism. 2010;7(3):52-53
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Metformin: a therapeutic opportunity in breast cancer
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Abstract
Obesity and metabolism. 2010;7(3):53-55
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A quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies
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Abstract
Obesity and metabolism. 2010;7(3):57-57
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Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis
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Abstract
Obesity and metabolism. 2010;7(3):57-58
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Adipose tissue inflammation: are small or large fat cells to blame?
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Abstract
Obesity and metabolism. 2010;7(3):58-59
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LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance
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Abstract
Obesity and metabolism. 2010;7(3):59-60
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Obesity without established comorbidities of the metabolic syndrome is associated with a proinflammatory and prothrombotic state, even before the onset of puberty in children
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Abstract
Obesity and metabolism. 2010;7(3):60-60
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Leptin therapy in lipodystrophy
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Abstract
Obesity and metabolism. 2010;7(3):60-61
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The effect of metformin on anthropometrics and insulin resistance in patients receiving atypical antipsychotic agents:a meta-analysis
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Abstract
Obesity and metabolism. 2010;7(3):62-62
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Lechenie morbidnogo ozhireniya u vzroslykh. Proekt Natsional'nykh klinicheskikh rekomendatsiy
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Abstract
Obesity and metabolism. 2010;7(3):64-68
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Vliyanie orlistata na vistseral'nyy zhir posle liposaktsii
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Abstract
Obesity and metabolism. 2010;7(3):69-70
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