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The first experience with selective blood collection from the inferior petrosal sinuses in Russia (case reports)

Abstract


This paper reports two clinical cases of ACTH-dependent hypercorticism. Difficulties encountered in differential diagnosis of this condition were due to poor informative value of routine diagnostic methods. The use of selective blood collection from the inferior petrosal sinuses (for the first time in Russia) greatly facilitated the choice of the adequate treatment strategy. A detailed description of clinical features of ACTH-dependent hypercorticism in two young women is presented along with the results of laboratory and instrumental studies. Technical aspects of selective blood collection from the inferior petrosal sinuses in conjunction with the desmopressin stimulation protocol are considered. Indications for the use of this diagnostic method under real clinical conditions are proposed. Results of the study are discussed with reference to the treatment strategy chosen for the management of ACTH-dependent hypercorticism and the outcome of surgical intervention.

Ivan Ivanovich Dedov

Ivan Ivanovich Sitkin

Zhanna Evgen'evna Belaya

Email: janne-be@mtu-net.ru

Evgeniya Ivanovna Marova

Elena Georgievna Przhiyalkovskaya

Oleg Valer'evich Remizov

Lyudmila Yakovlevna Rozhinskaya

I I Dedov

I I Sitkin

Zh E Belaya

E I Marova

O V Remizov

L Ya Rozhinskaya

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CrossRef     4 citations

  • Sitkin II, Malygina AA, Belaya ZE, Rozhinskaya LY, Buryakina SA. Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism. Endocrine Surgery. 2018;12(2):89. doi: 10.14341/serg9752
  • Nadezhdina EY, Rebrova OY, Ivashenko OV, Azizyan VN, Arapova SD, Grigoriev AY. Factors affecting the probability of recurrence of the Cushing’s disease within 3 years after effective neurosurgical treatment. Endocrine Surgery. 2018;12(2):70. doi: 10.14341/serg9761
  • Melnichenko GA, Dedov II, Belaya ZE, Rozhinskaya LY, Vagapova GR, Volkova NI, et al. Cushing’s disease: the clinical features, diagnostics, differential diagnostics, and methods of treatment. Problems of Endocrinology. 2015;61(2):55. doi: 10.14341/probl201561255-77
  • Nadezhdina EY, Belaya ZE, Rozhinskaya LY, Azyzjan VN, Ivashenko OV, Ilyin AV, et al. The role of intrа and postoperative ACTH and cortisol levels measurement in patients with Cushing’s disease as an early predictors of remission.. Endocrine Surgery. 2017;11(1):28. doi: 10.14341/serg2017128-37

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Copyright (c) 2009 Dedov I.I., Sitkin I.I., Belaya Z.E., Marova E.I., Przhiyalkovskaya E.G., Remizov O.V., Rozhinskaya L.Y., Dedov I.I., Sitkin I.I., Belaya Z.E., Marova E.I., Remizov O.V., Rozhinskaya L.Y.

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