Isolated left ventricular diastolic dysfunction in diabetes mellitus: opinions change

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Aim — to compare the features of diastolic dysfunction (DD) with preserved left ventricular (LV) ejection fraction (EF) in patients with diabetes mellitus type 2 (DM2) with arterial hypertension (AH) and in patients with essential hypertension (EH) without diabetes.

Material and methods. The study involved 87 patients with DD with preserved LV EF: 53 patients with DM2 with AH and 34 patients EH without diabetes. Transthoracic echocardiography was performed by ultrasonic imaging system iE33 xMATRIX («Philips», USA). DD was determined in a complex: type on the basis of the ratio parameters of pulsed-wave (E/A) and tissue (e/a) Doppler; and severity on the Е/e values and pulmonary capillary wedge pressure (PCWP). Myocardial contractile function was assessed by traditional LVEF by Simpson and more exactly, in details on the basis of the longitudinal, radial and circular deformation of the LV myocardium by speckle-tracking echocardiography (using the program Q-lab 3.0 Advanced Ultrasound Quantification software).

Results. The groups were comparable in clinical characteristics. The average level of HbA1c in patients with DM2 was 8.2±1.7%. The average LV EF by Simpson in the EH group was 59.9±8.1, in DM2 — 58.3±6.7 (p=0.228). There were more severe disorders of LV Diastolic function in DM2 patients: the values of E/e (p=0.000) and PCWP (p=0.001) were significantly higher in diabetic patients (14,1±5,5 and 15,3±4,7 mm Hg) than in EH (9.7±2.3 and 11.9±1.3 mm Hg). Although that the LV EF (by traditional echocardiographic method of Simpson) was preserved in both groups , the LV global longitudinal strain (12.4±3.0) was significantly lower in DM2 (p=0.005), than patients with EH (16.6±2.0) by speckle-tracking echocardiography.

Conclusion. Severity of LV DD are harder in Patients with diabetes and hypertension, than in patients with EH with the similarity of clinical manifestations and data of traditional echocardiographic methods. There were found initial disorders of LV longitudinal myocardial fibers contraction by speckle-tracking echocardiography in patients with DM and preserved LV EF. The combination of impairment of systolic and diastolic function in diabetes is inseparable. Early development of combined systolic and diastolic dysfunction in DM2 is associated with a poor prognosis: a higher risk of early development of atrial fibrillation, ventricular arrhythmias and progressive heart failure.

Svetlana S. Kukharenko

Author for correspondence.
Endocrinology Research Centre, Moscow
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow


Maria N. Yadrikhinskaya
Endocrinology Research Centre, Moscow
Russian Federation, MD, PhD

11 Dm.Ulyanova street, 117036 Moscow

Olga A. Shatskaya
Endocrinology Research Centre, Moscow
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow


Elena N. Drozdova
Endocrinology Research Centre, Moscow
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow


Aleksandra L. Kudryashova
Endocrinology Research Centre, Moscow
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow


Marina V. Shestakova
Endocrinology Research Centre, Moscow
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow

MD, PhD, Professor

Ivan I. Dedov
Endocrinology Research Centre, Moscow
Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow

MD, PhD, Professor

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Copyright (c) 2017 Kukharenko S.S., Yadrikhinskaya M.N., Shatskaya O.A., Drozdova E.N., Kudryashova A.L., Shestakova M.V., Dedov I.I.

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