Is visceral obesity the cause of obesity paradox?

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Abstract


Obesity is one of the 10 risk factors of death. Many epidemiological studies have shown that overweight and obesity are associated with 44% cases of diabetes type 2, and 23% of cases of coronary heart disease. The body mass index (BMI) is traditionally a diagnostic marker of obesity and overweight are considered. However, in the last 15 years, there has been work on the «paradox» of obesity. So the obese long-term prognosis and stroke are more favorable than individuals without excess weight and obesity. A deeper analysis of the data showed that the highest risk of developing cardiovascular disease and disorders of carbohydrate metabolism associated with visceral obesity. This is largely due to metabolic disorders occurring on the background of visceral obesity, such as insulin resistance, hyperglycemia, dyslipidemia, an imbalance of adipokines and markers of inflammation. These changes in individuals with visceral obesity can occur regardless of the value of BMI.


Daria A. Borodkina

Author for correspondence.
alpheia@mail.ru
SPIN-code: 8666-3500
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo; Kemerovo regional clinical hospital, Kemerovo
Russian Federation, 6 Sosnoviy boul., 650002  Kemerovo

MD

Olga V. Gruzdeva

o_gruzdeva@mail.ru
SPIN-code: 4322-0963
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo;
Russian Federation, 6 Sosnoviy boul., 650002 Kemerovo

MD, PhD

Ludmila V. Kvitkova

kvitkova_lv@mail.ru
SPIN-code: 4678-1318
Kemerovo State Medical University, Kemerovo
Russian Federation, 22a, Voroshilov street, Kemerovo, 650029

MD, PhD, Professor

Olga L. Barbarash

olb61@mail.ru
SPIN-code: 5373-7620
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo; Kemerovo State Medical University, Kemerovo
Russian Federation, 6 Sosnoviy boul., 650002 Kemerovo

MD, PhD, Professor

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