Уважаемые пользователи!

Данный сайт содержит информацию для людей с медицинским образованием и специалистов здравоохранения.
Входя на сайт, Вы подтверждаете свое согласие с Условиями использования и Политикой конфиденциальности.



Dear visitor!
This site contains medical information for healthcare professionals.
You can go further, if you agree with Terms and Conditions and Privacy Policy on this site.

A case of combination of two autoimmune diseases: type 1 diabetes mellitus and systemic scleroderma in a 13-year-old girl

Cover Page
Open Access Open Access
Restricted Access Subscription Access

Abstract


Systemic scleroderma is an autoimmune disease of the connective tissue of unknown etiology. It is characterized by skin induration, lesions in the musculoskeletal system and the internal organs, and the Raynaud syndrome. An important component in pathogenesis of systemic scleroderma is disturbance of microcirculation involving endothelial proliferation and destruction, wall thickening and narrowing of the microvessel lumen, vasospasm, hemocyte aggregation, stasis, deformation and reduction of the capillary network (obliterating microangiopathy). Two main forms of the disease are distinguished: the diffuse and localized ones. The systemic nature of the diffuse form of systemic scleroderma is most obvious in the skin, but the digestive tract, respiratory organs, kidneys and the cardiovascular, endocrine, musculoskeletal and genitourinary systems are also affected. The incidence rate of systemic scleroderma is 6.3—12 cases per million population. Single case reports on scleroderma combined with other autoimmune diseases, including type 1 diabetes mellitus, in children and adolescents are available in literature. A rare case of a combination of two autoimmune diseases, type 1 diabetes mellitus and systemic scleroderma, in a 13-year-old girl is reported in this paper.


Elena V. Titovich

Endocrinology Research Centre

Author for correspondence.
Email: lenatitovich@mail.ru
ORCID iD: 0000-0001-7821-3979
SPIN-code: 7994-0797

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

Ekaterina A. Andrianova

Endocrinology Research Centre

Email: katandr13@list.ru
ORCID iD: 0000-0002-6611-8170
SPIN-code: 7496-4580

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

  • Гусева Н.Г. Системная склеродермия. В кн.: ревматология: национальное руководство. / Под ред. Насонова Е.Л., Насоновой В.А. — М.: ГЭОТАР-Медиа; 2008. — С. 447—467. [Guseva NG. Sistemnaya sklerodermiya. In: Nasonov EL, Nasonova VA, editors. Revmatologiya: natsional’noe rukovodstvo. Moscow: GEOTAR-Media; 2008;447-467. (In Russ.)].
  • Гусева Н.Г. Системная склеродермия и склеродермическая группа болезней. // РМЖ. — 2000. — Т. 8. — № 9. — С. 383—387. [Guseva NG. Sistemnaya sklerodermiya i sklerodermicheskaya gruppa bolezney. RMJ. 2000;8(9):383-387. (In Russ.)].
  • Невская Т.А., Гусева Н.Г. Псевдосклеродермический синдром при сахарном диабете. // Научно-практическая ревматология. — 2001. — № 5. — С. 79—84. [Nevskaya TA, Guseva NG. Pseudosclerodermal syndrome in diabetes mellitus. Science Practical rheumatology. 2001;(5):79-84. (In Russ.)].
  • Tseng CC, Chang SJ, Tsai WC, et al. Reduced incidence of type 1 diabetes and type 2 diabetes in systemic sclerosis: a nationwide cohort study. Joint Bone Spine. 2016;83(3):307-313. doi: 10.1016/j.jbspin.2015.06.017.
  • Zeglaoui H, Landolsi H, Mankai A, et al. Type 1 diabetes mellitus, celiac disease, systemic lupus erythematosus and systemic scleroderma in a 15-year-old girl. Rheumatol Int. 2010;30(6):793-795. doi: 10.1007/s00296-009-0988-2.

Supplementary files

Supplementary Files Action
1. Linear focus of deep atrophy of the skin and subcutaneous tissue, passing into the induration area, on the inner surface left hip and lower leg. View (3MB) Indexing metadata

Views

Abstract - 59

PDF (Russian) - 0

Remote (Russian) - 1

PlumX


Copyright (c) 2018 Titovich E.V., Andrianova E.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.