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Statin administration is associated with higher IGF-1 levels in patients without diabetes mellitus

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Abstract


Background: Research makes it clear that the IGF-1 level correlates with cardiovascular disease, chronic heart failure, and mortality. Yet, little is known about the effect of statins on IGF-1.

Aims: to evaluate the effect of statin treatment on IGF-1 and its association with a cardiovascular risk.

Material and methods: The study included 115 patients (mean age, 55.8±6.1 years) who either were overweight or had mild obesity (body mass index 28.6±3.8 kg/m2) without diabetes. Group 1 consisted of 70 patients with verified coronary artery disease receiving statin therapy; group 2 included 45 healthy subjects. Coronary angiography and treadmill test were used to diagnose coronary artery disease. Impaired glucose tolerance and total cholesterol, triglycerides, LPHD, LPLD, fibrinogen, and IGF-1 levels were evaluated in all the subjects. Heart chamber geometry was assessed by echocardiography.

Results: The IGF-1 level was significantly higher in group 1 compared to the control group (196 and 167 ng/ml, respectively; р=0.014). Serum levels of IGF-1 were associated with duration of statin therapy (R=0.311; p=0.000), stage of hypertension (R=0.187; p=0.04), fibrinogen (R=0.274; p=0.033), TG (R=0.316; p=0.006), total cholesterol (R=–0.213; p=0.016), LPLD (R=–0.184; p=0.038), smoking (R=0.3; p=0.009), ejection fraction (R=0.298; p=0.041), end-diastolic volume (R=0.422; p=0.036), end-systolic volume (R=0.407; p=0.042), end-diastolic dimension (R=0.27; p=0.014), interventricular septal thickness (R=0.247; p=0.02), and left ventricular posterior wall thickness (R=0.258; p=0.019). Rosuvastatin dose positively correlated with the IGF-1 level (R=0.521; p=0.028).

Conclusions: Statin administration is associated with higher IGF-1 levels in patients without diabetes. High IGF-1 level correlates with the risk factors of coronary artery disease: hypertension, lipid profile, and fibrinogen level and has an adverse effect on chronic heart failure by altering the cardiac remodeling.


Olga V. Shpagina

Endocrinology Research Centre

Author for correspondence.
Email: shpagina_olga@mail.ru
ORCID iD: 0000-0002-9033-6354
SPIN-code: 3114-2272

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, postgraduate student

Irina Z. Bondarenko

Endocrinology Research Centre

Email: iz_bondarenko@mail.ru
ORCID iD: 0000-0002-5178-6029
SPIN-code: 4524-4803

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

Galina S. Kolesnikova

Endocrinology Research Centre

Email: kolesnikova@endocrincentr.ru
ORCID iD: 0000-0002-8698-0681
SPIN-code: 7716-9680

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

PhD

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Copyright (c) 2018 Shpagina O.V., Bondarenko I.Z., Kolesnikova G.S.

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