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Health status of children conceived by assisted reproductive technologies: endocrinologist’s position

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Abstract


Assisted reproductive technologies (ART) are currently widely used around the world because of the increased prevalence of infertility (presently, about 15% of married couples suffer from infertility), as well as the increased access to treatment and public funding for this method. Hence, the number of children conceived by ART is steadily increasing every year.

This review focuses on the pressing problem of the health status of children conceived by assisted reproductive technologies (ART) by analyzing modern publications on the state of physical, gonadal and psychosomatic development, features of the endocrine system and cardiometabolic diseases, the risk of imprinting changes, congenital malformations and oncological disorders.

The data presented that there is no increased risk of childhood cancer or deterioration in quality of life. However, it is expected that the cardiovascular and metabolic risk factors found in childhood can worsen in later life and may ultimately be responsible for chronic cardiometabolic disease. Furthermore, the issue of fertility, especially in the male population conceived by ART, remains open, thus requiring additional longer-term research.


Zinaida S. Zyuzikova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: zyuzikova.z.s@gmail.com
ORCID iD: 0000-0001-6709-8231
SPIN-code: 6731-8990

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD student

Natalya N. Volevodz

Endocrinology Research Centre

Author for correspondence.
Email: nnvolevodz@mail.ru
ORCID iD: 0000-0001-6470-6318
SPIN-code: 1127-0933

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD, Professor

Olga R. Grigoryan

Endocrinology Research Centre

Email: iceberg1995@mail.ru
ORCID iD: 0000-0003-4979-7420
SPIN-code: 3060-8242

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD

Elena I. Degtyareva

National Medical Research Center of Obstetrics, Gynecology and Perinatology

Email: iceberg1995@mail.ru
ORCID iD: 0000-0002-8341-4449
SPIN-code: 5641-6913

Russian Federation, 4, akademika Oparina street, Moscow, 117997

MD, PhD

Ivan I. Dedov

Endocrinology Research Centre

Email: dedov@endocrincentr.ru
ORCID iD: 0000-0002-8175-7886
SPIN-code: 5873-2280

Russian Federation, 11, Dm. Ulyanova street, Moscow, 117036

MD, PhD, Professor

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Copyright (c) 2018 Zyuzikova Z.S., Volevodz N.N., Grigoryan O.R., Degtyareva E.I., Dedov I.I.

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