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Correlation between type 2 diabetes mellitus and air pollution with suspended particles

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Abstract


The review presents the modern concept of the relationship between air pollution with fine particulate matter (PM) and the prevalence of diabetes mellitus (DM). The role of PM in the pathogenesis of DM, in particular, DM2, depending on their size, origin, chemical composition, and concentration in the air is discussed. For this purpose, we used materials from the articles indexed in the PubMed and RSCI databases. Road transport-related PM, containing intermediate valence metals are believed to be the most dangerous ones. Long-term exposure to high concentrations of fine and ultrafine PM is associated with the risk of type 2 diabetes and mortality. Short-term exposure to PM causes vascular insulin resistance and inflammation triggered by oxidative stress in the lungs. Oxidative stress caused by exposure to PM is the central stage of inflammatory reactions, leading to release of pro-inflammatory cytokines from cells and systemic inflammation. Exposure to PM sized 2.5 microns or less results in significant increase in expression of proinflammatory genes and activation of corresponding signaling pathways. Involvement of PM into impairment of glucose homeostasis and increase in inflammation in adipose tissue, liver, and central nervous system has been confirmed in models and experimental studies. The role of air pollution with PM in the pathogenesis of type 2 diabetes is still not fully understood, especially at the molecular and cellular level. The development of formalized descriptions of the processes mediating the effect of PM on the human body will provide better understanding of the role of air pollution with suspended particles in the pathogenesis of various diseases and, in particular, DM2, which can contribute to improvement of treatments and preventive measures.


Alla F. Kolpakova

Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences

Author for correspondence.
Email: kolpakova44@mail.ru
ORCID iD: 0000-0001-5544-2744
SPIN-code: 6318-0028

Russian Federation, 630090, Novosibirsk, prosp. akad. Rzhanova, 6

MD, PhD, professor

Ruslan N. Sharipov

BIOSOFT.RU LLC; Novosibirsk State University

Email: shrus79@gmai.com
ORCID iD: 0000-0003-2182-5493
SPIN-code: 1214-2918

Russian Federation, 11-41/1, Russkaya str., Novosibirsk, 630058; 1, Pirogova street, Novosibirsk, 630090

project manager; senior teacher

Oxana A. Volkova

Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Email: ov@bionet.nsc.ru
ORCID iD: 0000-0003-3357-3297
SPIN-code: 8803-1300

Russian Federation, 10, prosp. akad. Lavrenjeva, Novosibirsk, 630090

PhD

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Supplementary files

Supplementary Files Action
1. A formalized description of the effect of PM2.5 on the development of insulin resistance and systemic inflammation (the processes underlying the pathogenesis of diabetes). View (864KB) Indexing metadata

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Copyright (c) 2018 Kolpakova A.F., Sharipov R.N., Volkova O.A.

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