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Sustained ventricular tachycardia in a patient with a single ventricle of the heart and a pheochromocytoma

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Abstract


A pheochromocytoma is a rare tumor that develops from adrenomedullary chromaffin cells and produce ones or more catecholamines, including adrenaline, norepinephrine, and dopamine. On rare occasions a pheochromocytoma is hormonally inactive. Cyanotic heart disease is also a relatively rare pathology. One of its least frequently occurring variants is the single ventricle of the heart. Presumably, in patients with cyanotic heart defects, the occurrence of pheochromocytes and paragangliomas will be higher due to the presence of certain germinative and somatic mutations. In cyanotic heart defects, the development of malignant arrythmias is one of the frequent causes of death. A combination of a pheochromocytoma with a single ventricle of the heart is extremely rare: only eight such cases have been described in the literature. This article describes a young patient with a unique case of a single ventricle of the heart, pheochromocytoma and sustained ventricular tachycardia. The cause of the ventricular tachycardia, in all likelihood, was inappropriate medical care – in this case, a prescription for verapamil. The surgical excision of the pheochromocytoma and the referral of the patient for cardiac surgery became possible only after correcting the antihypertensive and antiarrhythmic therapy. Verapamil was replaced with a combination of doxazosin and amiodarone, resulting in relatively satisfactory blood pressure readings and sinus rhythm.


Konstantin V. Melkozerov

Endocrinology Research Centre

Email: melkozerovkv@gmail.com
ORCID iD: 0000-0002-7328-6316
SPIN-code: 5307-9820

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD, PhD

Alexander B. Kuznetsov

Endocrinology Research Centre

Email: abkuznetsoff@yandex.ru
ORCID iD: 0000-0002-9008-6893
SPIN-code: 8253-4026

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD, PhD

Victor Yu. Kalashnikov

Endocrinology Research Centre

Email: victor9368@gmail.com
ORCID iD: 0000-0001-5573-0754
SPIN-code: 5342-7253

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD, PhD, Professor

Fatima М. Abdulkhabirova

Endocrinology Research Centre

Email: a-fatima@yandex.ru
ORCID iD: 0000-0001-8580-2421
SPIN-code: 2462-1115

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD, PhD

Sergey N. Kuznetsov

Endocrinology Research Centre

Email: kuznetsov_enc@mail.ru
ORCID iD: 0000-0001-8558-7725
SPIN-code: 9870-2578

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD, PhD

Anna M. Gorbacheva

Endocrinology Research Centre

Author for correspondence.
Email: ann.gorbachewa@yandex.ru
ORCID iD: 0000-0003-2669-9457
SPIN-code: 4568-4179
Scopus Author ID: 57190977461
ResearcherId: F-2798-2018

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD

Ivan I. Dedov

Endocrinology Research Centre

Email: dedov@endocrincentr.ru
ORCID iD: 0000-0002-8175-7886
SPIN-code: 5873-2280

Russian Federation, 11 Dm.Ulyanova street, 117036 Moscow, Russia

MD, PhD, Professor

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Supplementary files

Supplementary Files Action
1. Fig. 1. Electrocardiogram on admission. Monomorphic ventricular tachycardia is recorded. View (527KB) Indexing metadata
2. Fig. 2. Echocardiography data. View (386KB) Indexing metadata

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Copyright (c) 2019 Melkozerov K.V., Kuznetsov A.B., Kalashnikov V.Y., Abdulkhabirova F.М., Kuznetsov S.N., Gorbacheva A.M., Dedov I.I.

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